June: a lot of mosquitoes, muddy and slick sections due to late breakup make it a little more challenging in May and June; long daylight is a plus already early in the season.
July: the road is drier, long daylight hours make driving easy; there are less mosquitoes by the end of July
August: less mosquitoes, it can be dry or rainy (August generally has more rainy days than July); fog in the early morning hours around Atigun Pass can be very thick be the end of August. Always check the road conditions before you drive.
September: conditions are usually pretty good until mid of September, although snow storms are possible, especially around Atigun Pass. Almost no mosquitoes anymore but it gets dark at night
October - April: winter conditions